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目的:探讨测定心肌型脂肪酸结合蛋白(H-FABP)在临床诊断早期急性心肌梗死的应用效果。方法:选择65例胸痛患者采用快速检测患者发病0~3 h,3~6 h和6 h后血清H-FABP,并与常规静脉血心肌肌钙蛋白cTnⅠ肌酸激酶同工酶(CK-MB)结果比较,分析3种心肌标志物在诊断不同发病时段AMI的敏感性和特异性。结果:在0~3 h和3~6 h时段诊断AMI的敏感性H-FABP(66.7%、92.3%)明显高于cTnⅠ(33.3%、61.5%)CK-MB(0%、61.5%);特异性方面与CK-MB相当但明显优于cTnⅠ。结论:H-FABP在AMI发生3 h内较cTnI和CK-MB更具有早期诊断实用价值。
Objective: To investigate the clinical application of H-FABP in early diagnosis of acute myocardial infarction. Methods: Sixty-five patients with chest pain were enrolled in this study. Serum H-FABP levels at 0-3 h, 3-6 h and 6 h after onset were measured and compared with routine venous blood cardiac troponin cTnI creatine kinase (CK-MB) ) Results were compared and analyzed three kinds of myocardial markers in the diagnosis of different stages of onset of sensitivity and specificity of AMI. Results: The sensitivity of H-FABP (66.7%, 92.3%) was significantly higher than that of cTnⅠ (33.3%, 61.5%) CK-MB (0%, 61.5%) at 0 ~ 3 h and 3 ~ Specificity is comparable to CK-MB but significantly better than cTnI. Conclusions: H-FABP is more useful for early diagnosis than cTnI and CK-MB within 3 h after AMI.