难治性癫痫是多年来困扰临床医生的常见问题,其重要特征是大部分患者对许多抗癫痫药物抵抗。随着研究的深入,人们越来越多的认识到耐药基因在难治性癫痫中的作用,而多药耐药基因在难治性癫痫中扮演着重要的角色。现对多药耐药基因的结构、功能、表达、逆转及其检测手段等方面做一综述。 Refractory epilepsy is a common problem that has plagued clinicians over the years and its important characteristic is that most patients are resistant to many antiepileptic drugs. With the deepening of research, people are more and more aware of the role of drug resistance genes in refractory epilepsy, and multidrug resistance genes play an important role in refractory epilepsy. Now multi-drug resistance gene structure, function, expression, reversal and detection methods and so on are reviewed.