新月体性肾小球肾炎用免疫荧光染色法分类可分为免疫复合物型(IC)、抗肾小球基底膜型以及无荧光反应的所谓pauci-immune型。其中以后一型居多,但尚不清楚是否与免疫机理有关,然而近年来,在此型肾炎和Wegener肉芽肿、结节性多动脉炎等有坏死性血管炎的患者血清中,都检出了抗中性粒细胞胞浆的自家抗体(ANCA),而引起了人们的关注。1982年以来的进一步研究表明,ANCA又分为两种,其一是弥 Crescentic glomerulonephritis by immunofluorescence staining can be divided into immune complex type (IC), anti-glomerular basement membrane type and non-fluorescent reaction called pauci-immune type. Of which a type after most, but it is not clear whether the immune mechanism, but in recent years, in this type of nephritis and Wegener granuloma, polyarteritis nodosa and other patients with necrotizing vasculitis serum were detected Anti-neutrophil cytoplasmic autoantibodies (ANCA), and attracted people’s attention. Further research since 1982 shows that ANCA is divided into two types, one is Mi