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[目的]分析附子理中汤加减联合化疗对晚期胃癌脾胃虚寒型患者外周血T细胞及生活质量影响。[方法]选取我科2013年6月~2014年6月内镜下或术中病理诊断明确,的晚期胃癌患者共120例。随机数字表法将患者分为实验组和对照组,对照组予以奥沙利铂+卡培他滨化疗,实验组在对照组基础上,加用附子理中汤加减治疗。对比两组患者治疗前和治疗两个周期后外周血T细胞、卡氏评分(Karnofsky评分,KPS)和生活质量评定(Quality of life,QOL)。对比2组患者治疗2个周期后的近期疗效和不良反应发生率。[结果]2组患者治疗2个周期后的CD~(3+)、CD~(4+)和CD~(4+)/CD~(8+)细胞水平、KPS和QOL评分显著高于治疗前,P<0.05;实验组疗2个周期后的CD~(3+)、CD~(4+)和CD~(4+)/CD~(8+)细胞水平、KPS和QOL评分显著高于对照组,P<0.05。实验组和对照组治疗后近期疗效差异无统计学意义,P>0.05。2组患者化疗不良反应发生率差异无统计学意义,P>0.05。[结论]晚期胃癌患者化疗时加用附子理中汤加减可显著改善患者免疫水平和生活质量。
[Objective] To analyze the effect of Fuzi Lizhong Decoction combined with chemotherapy on T cells and quality of life in patients with advanced gastric cancer with spleen and stomach deficiency type. [Methods] A total of 120 patients with advanced gastric cancer who were diagnosed endoscopically or intraoperatively from June 2013 to June 2014 were selected. The patients were divided into experimental group and control group by random number table method. The control group was treated with oxaliplatin + capecitabine. The experimental group was treated with Fuzi Lizhong Decoction on the basis of the control group. Peripheral blood T cells, Karnofsky score (KPS) and quality of life (QOL) were compared between the two groups before and after treatment. The short-term efficacy and incidence of adverse reactions after 2 cycles of treatment were compared between the two groups. [Results] The levels of CD ~ (3 +), CD ~ (4+) and CD ~ (4 +) / CD ~ (8+) cells after 2 cycles of treatment in both groups were significantly higher than those of the treatment (P <0.05). The levels of CD ~ (3 +), CD ~ (4+) and CD ~ (4 +) / CD ~ (8+) cells in the experimental group after 2 cycles of treatment were significantly higher In the control group, P <0.05. There was no significant difference in the short-term curative effect between the experimental group and the control group after treatment. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05), P> 0.05. [Conclusion] Addition of Fuzi Lizhong Decoction in chemotherapy of advanced gastric cancer patients can significantly improve patients’ immune status and quality of life.