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目的 :分析影响严重急性呼吸综合征 (SARS)患者预后的诸因素 ,以指导临床救治及疗效判定。 方法 :采用 SPSS11.0及 SDAS软件回顾性分析 16 5例临床确诊的重症 SARS患者的临床特征 ,确定影响 SARS转归的诸因素。 结果 :(1)年龄与预后显著相关 (r=0 .5 0 6 ,P<0 .0 0 1) ,≤ 5 0岁与 >5 0岁患者的病死率分别为 4 .0 8%及 5 3.3% (P<0 .0 1) ;(2 )有无基础病变与预后显著相关 (r=0 .4 5 7,P<0 .0 0 1) ,其病死率分别为 5 4 .5 %及 7.5 % (P<0 .0 1) ;(3)入院时 CK、L DH、CK- MB、AST、HBDH、尿素改变、肌酐改变与预后相关 ,Pearson相关系数分别为 0 .5 2 0、0 .4 97、0 .4 85、0 .4 71、0 .35 8、0 .371及 0 .339(P均 <0 .0 1) ;(4 )病情最重时淋巴细胞绝对数 (L y)、Plt计数、尿常规改变、L DH、HBDH、CK- MB、AST、尿素、CK、TB、尿素改变、肌酐改变、呼吸频率、低氧血症程度、胸片受累肺叶数与预后相关 ,Pearson相关系数分别为 - 0 .2 5 7、- 0 .4 73、0 .5 4 4、0 .788、0 .6 96、0 .5 86、0 .4 81、0 .379、0 .36 8、0 .32 9、0 .2 79、0 .4 14、0 .72 8、0 .76 5及 0 .36 6 (P均 <0 .0 5 )。 结论 :重症 SARS患者转归与年龄 ,病前基础病变 ,病情最重时的 L y、Plt、尿常规改变、呼吸频率、低氧血症?
Objective: To analyze the factors influencing the prognosis of patients with severe acute respiratory syndrome (SARS) so as to guide the clinical treatment and the determination of therapeutic effect. Methods: The clinical features of 165 clinically diagnosed SARS patients were retrospectively analyzed by SPSS11.0 software and SDAS software to determine the factors affecting the outcome of SARS. Results: (1) There was a significant correlation between age and prognosis (r = 0.0560, P <0.001). The case fatality rates of patients ≤50 and> 50 were 4.80% and 5% respectively 3.3% (P <0.01); (2) There was a significant correlation between the prognosis and the underlying disease (r = 0.47, P0.01) .The mortality rates were 54.5% And 7.5% respectively (P <0.01). (3) CK, L DH, CK-MB, AST, HBDH, urea change and creatinine were correlated with prognosis on admission. The Pearson correlation coefficients were 0.50 2, 0 .4 97,0 .4 85,0 .4 71,0 .35 8,0 .371 and 0 .339 (P <0.01); (4) The absolute value of the absolute number of lymphocytes (L L, HBDH, CK-MB, AST, urea, CK, TB, urea change, creatinine change, respiratory rate, hypoxemia, and the number of lobes affected by chest radiograph were correlated with prognosis , Pearson correlation coefficients were -0.227, -0.44, -0.54 4,0 .788,0 .6 96,0 .5 86,0 .4 81,0 .379,0. 36 8,0 .32 9,0 .2 79,0 .4 14,0 .72 8,0 .76 5 and 0 .36 6 (P <0.05). Conclusion: The outcome of severe SARS patients with age, pre-illness basic disease, the most serious condition of L y, Plt, urine routine changes, respiratory rate, hypoxemia?