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阐述肿瘤错配修复(mismatch repair,MMR)系统的组成和作用机制以及与肿瘤发生、发展的内在联系,展望错配修复基因hMLH1、hMSH 2与鼻咽癌的相关性,以期为鼻咽癌提供早期诊断和治疗的新指标。
To elucidate the composition and mechanism of tumor mismatch repair (MMR) system and its relationship with tumorigenesis and development, and to investigate the relationship between mismatch repair genes hMLH1 and hMSH 2 and nasopharyngeal carcinoma, so as to provide nasopharyngeal carcinoma New indicators of early diagnosis and treatment.