一、疟疾国外疟疾化学治疗方面的研究,主要是寻找治疗抗氯喹恶性疟原虫株感染的新药及配伍用药的方法。治疗原则为对氨苯甲酸抗剂如磺胺类、砜类配伍抗叶酸剂如氯胍类、乙胺嘧啶,使疟原虫不能合成叶酸,并阻止其二氢叶酸、四氢叶酸的代谢,从而限制其核酸的 First, the study of malaria chemotherapy in foreign countries, mainly to find new anti-chloroquine-resistant Plasmodium falciparum infection and compatibility of drug methods. Treatment principles for the ammonia benzoin agents such as sulfonamides, sulfone compatibility with antifolate agents such as proguanil, pyrimethamine, the parasite can not synthesize folic acid, and prevent its dihydrofolate, tetrahydrofolate metabolism, thus limiting Its nucleic acid