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采用超声雾化吸入1％卵蛋白生理盐水致敏，并以同法诱喘制备豚鼠哮喘模型45只，随机分成3组（治疗前组、治疗组、对照组），并设正常组15只．治疗组每天灌服GTT混悬液2ml（含GTT5mg），连续灌21d．治疗前组及对照组豚鼠气管及肺组织病理切片可见气管、支气管粘膜上皮细胞之间及粘膜下层，有多量嗜酸细胞及淋巴细胞浸润，粘膜上皮细胞脱落，杯状细胞脱颗粒等变应性炎症的表现．治疗组治疗后诱喘潜伏期显著延长，发作程度也显著减轻，诱喘的卵蛋白阈浓度有所增高，提示GTT对豚鼠哮喘有明显的平喘作用．治疗组治疗后气管。支气管各层组织中嗜酸细胞和淋巴细胞浸润减轻，粘膜上皮细胞脱落亦有改善，提示GTT对豚鼠气道变应性炎症有一定的治疗作用．
A total of 45 guinea pig asthma models were prepared by ultrasonic nebulization and inhalation of 1% ovalbumin saline. The guinea pig asthma models were randomly divided into 3 groups (pretreatment group, treatment group, and control group), and 15 normal groups were established. The treatment group received 2ml GTT suspension (containing GTT 5mg) per day for 21 days. Pathological sections of the trachea and lung tissue of the guinea pigs before treatment and in the control group can be seen between the trachea and bronchial epithelial cells and submucosa, with a large amount of eosinophils and lymphocyte infiltration, shedding of epithelial cells, degranulation of goblet cells, etc. The performance of inflammation. After treatment, the latency of asthma was significantly prolonged and the degree of attack was significantly reduced in the treatment group. The threshold concentration of egg albumin in asthma was increased, suggesting that GTT has a significant asthma effect on asthma in guinea pigs. The treatment group treated the trachea. The infiltration of eosinophils and lymphocytes in the bronchial layers was reduced, and the shedding of mucosal epithelial cells was also improved, suggesting that GTT has a certain therapeutic effect on airway allergic inflammation in guinea pigs.