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目的 评价羟基聚磷酸钙钠(Hydroxy poly-calcium nairium phosphate,HPA)与聚羟基丁酸酯(Polyhydroxybutyrate,PHB)联合使用修复骨缺损的效果。方法 采用HPA充填狗股骨人工缺损区,同时覆盖PHB膜,与PHB膜覆盖及空白对照作比较,通过组织形态学及定量检测,考察1周,1、2、3月缺损修复情况。结果 HPA与PHB联合组,2月内骨密度及形态优于PHB组,3月后二组相当,均优于空白对照组。结论 HPA与PHB联合使用,可早期获得骨缺损修复强度与外形并举的效果。
Objective To evaluate the effect of combined use of Hydroxy poly-calcium nairium phosphate (HPA) and polyhydroxybutyrate (PHB) in repairing bone defects. Methods HPA was used to fill the defect area of the femur and cover the PHB membrane at the same time. Compared with the PHB membrane covered and blank control, the defects were repaired in 1 week, 1, 2 and 3 months by histomorphometry and quantitative detection. Results Compared with PHB group, the BMD and morphology of HPA group and PHB group were better than that of PHB group in March. After 3 months, the two groups were equal, which were better than the blank control group. Conclusion The combination of HPA and PHB can achieve the effect of simultaneously increasing the strength and appearance of bone defects.