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目的 : 探讨带状疱疹并发脑膜脑炎的相关因素及发病机制。方法 : 汇集了山东省 12家省市级大医院皮肤科及神经内科住院患者的资料 ,共有 45例 ,从临床及实验室等方面进行了总结分析。结果 : 认为年龄不是主要因素 ,各种原因导致的免疫抑制是重要因素 ,颅神经尤其是三叉神经眼支受累引起脑炎占首位 ,其次是肋间神经。结论 : 带状疱疹并发脑膜脑炎的机制是由于VZV直接侵入脑组织 ,也存在免疫机制 ,因此在治疗中要合理的运用抗疱疹病毒药物、糖皮质激素及对症治疗 ,一般预后还是好的。
Objective: To explore the related factors and pathogenesis of herpes zoster complicated with meningoencephalitis. Methods: A total of 45 cases of inpatients with dermatology and neurology from 12 provincial-level major hospitals in Shandong Province were collected, and their clinical and laboratory studies were summarized. Results: Age was not the main factor. Immunosuppression caused by various reasons was an important factor. Cranial nerves, especially the branches of the trigeminal nerve, were the most common cause of encephalitis, followed by intercostal nerves. Conclusion: The mechanism of herpes zoster complicated with meningoencephalitis is that VZV directly invades the brain tissue and immune mechanism exists. Therefore, it is good to use anti-herpes virus drugs, glucocorticoids and symptomatic treatment reasonably in the treatment.