Ménétrier病是一种临床罕见的、特殊类型的肥厚性胃炎,主要表现为胃体、胃底黏膜皱襞粗大、肥厚,扭曲成脑回状,同时伴有胃酸分泌减少及低蛋白血症。本文报道1例患者临床资料,并结合国内外文献报道,探讨本病的病因、发病机制、临床表现、诊断及治疗,以提高临床医师对该病的认识水平。 Ménétrier disease is a clinically rare and special type of hypertrophic gastritis characterized mainly by corpus follicles, thickening and hypertrophy of the gastric fundus, with a distortion of the brain’s gyrus, accompanied by reduced gastric acid secretion and hypoalbuminemia. This article reports one patient clinical data, combined with domestic and foreign literature reports to explore the etiology, pathogenesis, clinical manifestations, diagnosis and treatment in order to improve clinicians awareness of the disease.