目的观察顺铂软膏对小鼠皮肤颗粒细胞生成和体重的影响。方法昆明种小鼠25只 ,随机均分为5组 :空白对照组、迪维霜组、0 1 %顺铂软膏组、0 5 %顺铂软膏组、1 %顺铂软膏组。外用给药18d后 ,观察动物体重变化和皮肤病理学变化。结果与空白对照组比较,0.1 %～1 %顺铂软膏均明显增加皮肤颗粒细胞生成 (P<0.01) ,对体重增加的影响均明显小于迪维霜 (P>0.01) ,也未见明显的局部刺激。结论顺铂软膏可促进皮肤颗粒细胞生成 Objective To observe the effect of cisplatin ointment on granulosa cell production and body weight in mice. Methods 25 Kunming mice were randomly divided into 5 groups: blank control group, Diweishuang group, 01% cisplatin ointment group, 0.5% cisplatin ointment group, and 1% cisplatin ointment group. After 18 days of topical administration, changes in body weight and skin pathology were observed. Results Compared with the blank control group, 0.1% to 1% cisplatin ointment significantly increased the production of granulosa cells (P<0.01). The effect on body weight gain was significantly less than that of Diwei cream (P>0.01). There was no obvious effect. Local stimulation. Conclusion Cisplatin ointment can promote skin granule cell formation