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对山东某化工厂ＴＮＴ作业工人劳动卫生学调查结果发现，车间空气中ＴＮＴ浓度多数均超过国家最高容许浓度（ＭＡＣ＝１ｍｇ／ｍ３），工人皮肤污染严重。ＴＮＴ接触组工人血清肌酐和肌酸含量均极显著高于对照组（Ｐ＜０．０００５）。然而，ＴＮＴ接触组工人血清和尿中β２－ＭＧ含量高于正常值上限阳性检出率分别为８１．５４％和６６．６７％。动物实验表明，ＴＮＴ染毒大鼠血清肌酐和肌酸含量均显著高于对照组（Ｐ＜０．０５）。由此可见，似乎ＴＮＴ可轻度诱发肾小球滤过功能和肾近曲小管通渗性改变
A survey of labor hygiene of TNT workers in a chemical plant in Shandong found that most of the TNT concentrations in the air of the workshop exceeded the maximum allowable concentration of the country (MAC = 1 mg / m3) and workers’ skin was seriously polluted. Serum creatinine and creatine levels in TNT exposure group were significantly higher than those in control group (P <0.0005). However, the positive detection rates of β2-MG in serum and urine of TNT-exposed workers were 81.54% and 66.67%, respectively, higher than the upper limit of normal. Animal experiments show that TNT exposed rats serum creatinine and creatine levels were significantly higher than the control group (P <0.05). Thus, it seems that TNT can be mildly induced glomerular filtration and renal proximal tubule permeability changes