This paper describes an orthogonal experiment on the effect of water/cement ratio,water consumption per cubic meter,curing time,and type of sand on the response“resistance to chloride ion penetration”.A sea-sand containing concrete was used for the trials.An analysis of chloride ion diffusion coefficients at different factor levels was performed.A predictive model of chloride ion diffusion in concrete is developed through regression analysis.The experimental results show that when the water/cement ratio varies from 0.45 to 0.60,and the water consumption per cubic meter varies from 185 to 215 kg,and the curing time varies from 30 to 180 d then the size of the effects fall in the order(most significant first): curing time,type of sand,water consumption per cubic meter,and water/cement ratio.Chloride ion penetration is reduced,and better durability of the concrete is observed,with longer curing times,less water consumption per cubic meter,and a smaller water/cement ratio. This paper describes an orthogonal experiment on the effect of water / cement ratio, water consumption per cubic meter, curing time, and type of sand on the response “” resistance to chloride ion penetration ". A sea-sand containing concrete was used for the trials. An analysis of chloride ion diffusion coefficients at different factor levels was performed. A predictive model of chloride ion diffusion in concrete is developed through regression analysis. the experimental results show that when the water / cement ratio varies from 0.45 to 0.60, and the water consumption per cubic meter varies from 185 to 215 kg, and the curing time varies from 30 to 180 d then the size of the effects fall in the order (most significant first): curing time, type of sand, water consumption per cubic meter, and water / cement ratio. Chloride ion penetration is reduced, and better durability of the concrete is observed, with longer curing times, less water consumption per cubic meter, and a smaller water / cement ratio.