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促生长激素轴对卵巢功能的影响,近10年引起人们极大关注。生长激素释放因子(GRF)、胰岛素生长因子(IGF-I)可影响颗粒细胞功能,大鼠颗粒细胞中已发现GRF的受体及基因的蛋白结构,GH可加强FSH诱导的LH-hCG受体,增加雌争激素的产生。本文目的是评价小剂量GRF在月经规律妇女促卵泡生长发育的效果。研究选择了7名月经规律的妇女,年龄21～38岁(平均29岁)。病人经一个自发的对照周期和应用GRF的治疗周期,每位患者均以自己为对照,每次检查均需做阴道超声波测量卵泡数目、直经和子宫内膜厚度并需取血样化验FSH、LH、E_2、P、GH、IGF-1、IGF-I结合蛋白3,在治疗周期第2～11d早晨8～9点之间给
Growth hormone axis of ovarian function, the past 10 years has caused great concern. Growth hormone releasing factor (GRF) and insulin-like growth factor (IGF-I) can affect the function of granulosa cells. The protein structure of GRF receptors and genes has been found in rat granulosa cells. GH can enhance FSH-induced LH-hCG receptor , Increase the production of estrogen hormone. The purpose of this paper is to evaluate the effect of low-dose GRF on follicle growth in women with regular menstruation. Study selected seven menstruating women, aged 21 to 38 years (mean 29 years). Patients after a spontaneous control cycle and the treatment cycle using GRF, each patient to their own as a control, each examination need to do vaginal ultrasound to measure the number of follicles, straight and endometrial thickness and blood samples to be taken FSH, LH , E_2, P, GH, IGF-1 and IGF-I binding protein 3 were administered between 8 and 9 in the morning of the second to the 11th day of the treatment cycle