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目的 :探讨细胞间黏附分子 1(ICAM 1)、白细胞介素 6 (IL 6 )在变应性鼻炎鼻及支气管黏膜中的表达及意义。方法 :采用免疫组织化学方法检测ICAM 1、IL 6在 2 8例变应性鼻炎患者 (鼻炎组 )及 12例健康志愿者 (对照组 )的鼻、支气管黏膜中的表达。结果 :ICAM 1在鼻炎组鼻和支气管黏膜中的表达率分别为 10 0 .0 0 %和92 .86 % ,其差异无统计学意义 (P >0 .0 5 ) ;对照组鼻、支气管黏膜中ICAM 1表达率 (分别为 6 6 .6 7%和 5 8.33% )分别与鼻炎组 (分别为 10 0 .0 0 %和 92 .86 % )比较 ,差异均有统计学意义 (分别P <0 .0 1和P <0 .0 5 )。IL 6在鼻炎组鼻、支气管黏膜中的表达率分别为 10 0 .0 0 %、82 .14 % ,其差异无统计学意义 (P >0 .0 5 ) ;对照组鼻、支气管黏膜中IL 6表达率均为 4 1.6 7% ,分别与鼻炎组 (分别为 10 0 .0 0 %和 82 .14 % )比较 ,差异均有统计学意义 (分别P<0 .0 1和P <0 .0 5 )。结论 :ICAM 1、IL 6是呼吸道变态反应性炎症中的重要细胞因子 ,上、下呼吸道变应性炎症密切相关 ;同时治疗上、下呼吸道炎症性疾病 ,才能取得更好的治疗效果。
Objective: To investigate the expression and significance of intercellular adhesion molecule 1 (ICAM 1) and interleukin 6 (IL 6) in allergic rhinitis, nasal and bronchial mucosa. Methods: Immunohistochemistry was used to detect the expression of ICAM 1 and IL 6 in nasal and bronchial mucosa of 28 allergic rhinitis patients (rhinitis group) and 12 healthy volunteers (control group). Results: The expression rates of ICAM 1 in nasal and bronchial mucosa of rhinitis group were 100.0% and 92.86%, respectively, with no significant difference (P> 0.05). In the control group, nasal and bronchial mucosa The ICAM 1 expression rates (66.67% and 53.33%, respectively) were significantly different from those of the rhinitis group (100.0% and 92.86%, respectively) (P < 0 .0 1 and P <0. 0 5). The expression of IL-6 in nasal and bronchial mucosa of rhinitis group was 100.0% and 82.14%, respectively, with no significant difference (P> 0.05). In the control group, the expression of IL 6 were 41.67%, respectively, which were significantly different from rhinitis group (100.0% and 82.14%, respectively) (P <0.01 and P <0.01, respectively). 0 5). CONCLUSION: ICAM 1 and IL 6 are important cytokines in respiratory allergic inflammation, and are closely related to allergic inflammation of the upper and lower respiratory tract. At the same time, the treatment of upper and lower respiratory tract inflammatory diseases can achieve better therapeutic effect.