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再生医学的目的是为了减轻组织损伤所致的不可逆性功能损害,多种类型的干细胞可促进神经再生,发挥治疗作用。近来,在骨髓和其他组织中发现了一种数量极少的极小胚胎样干细胞(VSELs),其分子标志为Oct-4+CXCR4+SSEA-1+Sca-1+lin-CD45-,它们可动员到外周血中。在给予动员剂或组织损伤等应激情况下可向损伤区迁移,现在认为它是高度迁移的外胚层/生殖系源性的干细胞群,具有多能干细胞特征,能分化为三个胚层细胞,综上所述,极小胚胎样干细胞可能通过促进神经再生修复中枢神经系统损伤。
The purpose of regenerative medicine is to reduce irreversible damage caused by tissue damage, many types of stem cells can promote nerve regeneration, play a therapeutic role. Recently, a very small number of minimal embryonic-like stem cells (VSELs) have been found in bone marrow and other tissues with the molecular markers Oct-4 + CXCR4 + SSEA-1 + Sca-1 + lin-CD45- Mobilized to the peripheral blood. Migration to injured areas under stress conditions such as mobilization or tissue damage is now considered to be a highly migratory group of ectoderm / germline-derived stem cells characterized by pluripotent stem cells capable of differentiating into three germ cells, Taken together, Minimal embryonic-like stem cells may repair central nervous system damage by promoting nerve regeneration.