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渥曼青霉素(Wortmannin)是一种霉菌代谢产物,是磷脂酰肌醇3激酶(PI3K)的特异性抑制剂。本研究旨在通过Wortmannin抑制PI3K／Akt信号通路,观察胰腺癌细胞株增殖能力和凋亡抗性改变,阐明PI3K／Akt途径在胰腺癌细胞增殖和生存中的重要性,探寻治疗胰腺癌的新途径。
Wortmannin is a mold metabolite that is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). The aim of this study was to investigate the PI3K / Akt signaling pathway and to observe the proliferation and apoptosis resistance of pancreatic cancer cell lines by Wortmannin. To elucidate the importance of PI3K / Akt pathway in the proliferation and survival of pancreatic cancer cells, way.