apelin是血管紧张素Ⅱ-1型受体相关蛋白的天然内源性配体,具有调节心血管系统稳态、扩张血管、降低血压、调节免疫等多种生物学效应。apelin对心血管系统发挥的作用日益受到重视。鉴于apelin对脉管系统的作用,并从apelin和一氧化氮(NO)两者之间可能存在的关系以及apelin、NO与妊娠期高血压疾病之间可能存在的关系研究分析,apelin可能与妊娠期高血压疾病的发生发展、硫酸镁治疗妊娠期高血压疾病的机制有关。 Apelin is a natural endogenous ligand of angiotensin II-1 receptor related protein and has many biological effects such as regulating cardiovascular system homeostasis, dilating blood vessels, lowering blood pressure and regulating immunity. The role of apelin on the cardiovascular system is gaining more and more attention. In view of apelin on the role of the vasculature, and from apelin and nitric oxide (NO) may exist between the relationship and apelin, NO and pregnancy-induced hypertension may be the relationship between the study analysis, apelin may be related to pregnancy The occurrence and development of hypertension, magnesium sulfate treatment of hypertensive disorders in pregnancy mechanism.