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1974年Kucherlapati等人用鼠-人体细胞杂交所进行的研究证明E-GR结构基因存在于第8号染色体的短臂上。1976年de laChapelle报道,在带有获得性8号染色体三体的病例中,有3/4E-GR活性升高。然而,1977年Bitrant等人发现一例特发性获得性难治铁粒幼细胞贫血(IARSA)病例,其骨髓中存有8号染色体三体,但此酶水平却正常。因此,获得性8号染色体三体是否伴有E-GR活性升高仍存有争议。
In 1974 Kucherlapati et al. Used murine-human cell hybridization studies have shown that the E-GR structural gene is present on the short arm of chromosome 8. 1976 de la Chapelle reported that 3 / 4E-GR activity was elevated in cases with acquired trisomy 8 chromosomes. However, in 1977, Bitrant et al. Found a case of idiopathic acquired refractory ironglossary cell anemia (IARSA), in which chromosome 8 trisomy exists in the bone marrow, but the enzyme level is normal. Therefore, whether acquired trisomy 8 chromosome associated with elevated E-GR activity remains controversial.