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癫患者在癫发作间期,抑郁症发作很常见。病因学主要归纳为强制正常化现象、抗癫药物、偏侧化假说和个人心理因素影响等4方面;癫合并抑郁与神经递质如5-羟色胺(5-HT)、去甲肾上腺素、γ-氨基丁酸和谷氨酸等有关;癫患者抑郁的检测。临床医生应重视抑郁症的治疗,并从抗癫药物和5-HT再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)等药物中归纳出一些主要药物的功效。本文主要针对癫合并抑郁的病因、发病机制、检测方法及治疗等研究进展作介绍。
Epileptic patients in the epileptic seizure period, the onset of depression is very common. Etiology is mainly summarized as the phenomenon of forced normalization, antiepileptic drugs, lateral hypothesis and personal psychological factors such as 4 aspects; epilepsy with depression and neurotransmitters such as 5-HT, norepinephrine , Γ-aminobutyric acid and glutamate and other related; detection of depression in patients with epilepsy. Clinicians should pay attention to the treatment of depression and sum up the efficacy of some major drugs from drugs such as antiepileptic drugs and selective serotonin reuptake inhibitors (SSRIs). This article focuses on the etiology, pathogenesis, detection methods and treatment of epilepsy with depression and other research progress.