老年糖尿病人胰岛A、B细胞功能与血脂变化

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对1992年1月~1994年1月收治的老年糖尿病210例,作者观察了胰岛A、B细胞功能与血脂及血粘度的变化。老年NIDDM的口服葡萄糖耐量试验各时相血糖值均显著增高(P<0.01);胰岛素释放试验及C肽释放试验中,除空腹胰岛素及C肽值正常外,其余各时相值均明显降低,但其中有20例呈高胰岛素血症(9.5%);胰高糖素释放试验中,空腹与180分钟的胰高糖素值正常,其余各时相值均明显升高(P<0.01)。老年NIDDM的GHbA_(1c)及GHbA_1值显著增高(P<0.01),血胆固醇,甘油三脂,低密度脂蛋白,极低密度脂蛋白和全血粘度平均值均显著增高(P<0.01).而高密度脂蛋白及血浆粘度等无明显变化。老年NIDDM胰岛A、B细胞功能失调,并经常有高血脂及高粘血症,少数有高胰岛素血症,容易并发心、脑、肾、眼或足的并发症,因此治疗老年糖尿病时,还应加强治疗高血脂症及高粘血症,以减少致残或死亡。 From January 1992 to January 1994, 210 elderly patients with diabetes mellitus were treated. The authors observed the changes of pancreatic islet A, B cell function and blood lipid and blood viscosity. Elderly patients with NIDDM oral glucose tolerance test showed significantly increased blood glucose levels (P <0.01); insulin release test and C peptide release test, except fasting insulin and C peptide values ​​were normal, the rest of the time phase values ​​were significantly , But 20 of them were hyperinsulinemia (9.5%). In glucagon release test, the fasting and 180-hour glucagon values ​​were normal and the rest of the phases were significantly increased (P <0.01). The values ​​of GHbA_ (1c) and GHbA_1 in elderly NIDDM patients were significantly higher (P <0.01), mean values ​​of blood cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein and whole blood viscosity were significantly higher .01). The high-density lipoprotein and plasma viscosity and no significant change. Elderly NIDDM pancreatic islet A, B cell dysfunction, and often hyperlipidemia and hyperviscosity, a few have hyperinsulinemia, easy to complicated by heart, brain, kidney, eye or foot complications, so the treatment of diabetes in elderly, but also Should be strengthened treatment of hyperlipidemia and hyperviscosity to reduce disability or death.
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