SARS是一种严重的急性呼吸道传染病,病原已被确定,但目前其发病机制尚不清楚。通过对死亡病例的尸检病理观察,以及运用光镜、电镜、原位杂交、免疫组化、RT-PCR等实验技术手段进行的研究表明:SAPS是全身性疾病,损伤多个脏器,肺、免疫器官和全身小血管是病毒攻击的主要靶器官;由于SAILS患者T细胞与病情严重程度密切相关,因此说明T细胞在SARS病变过程中可能有重要意义;以免疫损伤为基础的发病机制理论将能较为满意地解释临床症状和实验室检查结果。 SARS is a serious acute respiratory disease, the pathogen has been identified, but its pathogenesis is not yet clear. Through the autopsy pathological observation of death cases and the research using light microscope, electron microscope, in situ hybridization, immunohistochemistry, RT-PCR and other experimental techniques, SAPS is a systemic disease that damages multiple organs, lungs, Immune organs and whole body small blood vessels are the main targets of virus attack. Because T cells in SAILS patients are closely related to the severity of the disease, it indicates that T cells may play an important role in the pathogenesis of SARS. The theory of pathogenesis based on immune injury Can be more satisfied with the interpretation of clinical symptoms and laboratory test results.