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目的:探讨氯氮平(clozapine,CZP)对心电图(ECG)的影响.方法:分析260例CZP治疗患者的ECG资料.结果:162例有ECG异常变化,高速62.31％,明显异常者经减量或停用CZP后,94.12％恢复正常.结论:CZP导致ECG异常发生率高,早期减量或停用CZP后,大部分患者的ECG能恢复正常.“,”Objective:To determine the effect of clozapine on ECG of patients.Methods:260 clozapine-treated inpatients were randomly enrolled for ECG analysis.Results:Abnormal changes of ECG were observed in 162 cases (62.31％) and 94.12％ of the renarkable changes could be returned to normal after a decrease or stop of clozapine taken.Conclusion:Clozapine could lead to abnormal ECG to a high degree.Most of the cases would be back to normal state of ECG when the above-mentioned step was started.