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一般认为,鼻咽癌与EB病毒、环境致癌物和促癌物,及遗传因素等有关。王衡文(1965)、湖南医学院(1977)及湛江医学院(1978)用化学致癌剂诱发大、小鼠鼻咽癌,均相继获得成功。区宝祥等(1982)用硫酸镍协同二亚硝基哌嗪,曾促发大鼠鼻咽癌。上述研究已在证实环境病因方面取得成果,但由EB病毒诱发的鼻咽癌迄今尚未见有报道。Ito等(1981),曾毅等(1983),曾将环境因素与病毒病因研究相结合,用大戟科(Euphorbiaceae)和瑞香科(Thymelaeaceae)植物提取物,诱发离体培养的Raji细胞产生EB病毒早期抗原,并促成EB病毒引起淋巴细胞转化。但此类植物在整体研究中对鼻咽癌的的发生有否作用还未见报道、为此,我们研究了广西苍梧及梧州鼻咽癌高发区常见的中草药,瑞香科的了哥王[Wikstroemia indica (L)C.A.Mey],与亚硝胺类致癌剂共同应用,对动物鼻咽癌发生
It is generally believed that nasopharyngeal carcinoma is related to EB virus, environmental carcinogens and carcinogens, and genetic factors. Wang Hengwen (1965), Hunan Medical College (1977) and Zhanjiang Medical College (1978) used chemical carcinogens to induce nasopharyngeal carcinoma in large and small mice, and all of them succeeded. District Baoxiang et al. (1982) used nickel sulfate in conjunction with dinitrosopiperazine to induce nasopharyngeal carcinoma in rats. The above studies have already achieved results in confirming the environmental etiology, but no nasopharyngeal carcinoma induced by EB virus has been reported so far. Ito et al. (1981) and Zeng Yi et al. (1983) combined environmental factors with viral etiology studies to induce EBs in vitro from Raji cells cultured in vitro using Euphorbiaceae and Thymelaeaceae plant extracts. Viral early antigens and contribute to EB virus cause lymphocyte transformation. However, whether or not such plants have affected the occurrence of nasopharyngeal cancer in the overall study has not yet been reported. For this reason, we studied the common Chinese herbal medicines in the high-incidence areas of Guangxi Cangbu and Cangzhou, and Ruixiang Branch’s brother [ Wikstroemia indica (L) CAMey], co-administered with nitrosamine carcinogens, for animal nasopharyngeal carcinogenesis