例1 男,17岁,出生后即发现腹部有一肿块,随年龄增长肿块逐渐增大。全身皮肤发黑且粗糙。酷似鱼鳞癣,自幼常易发烧,腹泻,头疼头晕,并伴鼻衄。体检:发育营养一般,神态清楚,贫血面容,双目视力0.4,听力传导差。皮肤除面部手掌外,全身遍体呈黑色类似鱼鳞覆盖体表,易脱屑后再生,无痒痛,以 Example 1 male, 17 years old, found after birth that there is a lump in the abdomen, with increasing age lumps gradually increased. Whole body skin is black and rough. It is similar to ichthyosis, since childhood, often prone to fever, diarrhea, headache, dizziness, accompanied by epistaxis. Physical examination: general nutrition, demeanor, anemic face, binocular vision 0.4, poor hearing transmission. In addition to the skin outside the face of the palm, the whole body was covered with black similar to the scale body surface, easy to desquamate after regeneration, no itch pain, with