Three new phenazine-type compounds,named phenazines SA-SC (1-3),together with four new natural products (4-7),were isolated from the fermentation broth of an earwig-associated Streptomyces sp.NA04227.The structures of these compounds were determined by extensive analyses of NMR,high resolution mass spectroscopic data,as well as single-crystal X-ray diffraction measurement.Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a biosynthetic pathway for these phenazine-type compounds.Additionally,compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (ACHE),and compound 3 showed antimicrobial activities against Micrococcus luteus.