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CXC趋化因子是一类结构功能相似、具有趋化吸引和活化作用的小分子蛋白,在介导局部和全身炎症反应中起重要作用。干扰素(IFN)是一种具有广谱抗病毒、抗肿瘤和免疫调节作用的可溶性糖蛋白,主要由单核细胞和淋巴细胞产生。IFN不仅可通过PKR、2’-5’OAS、Mx、ADAR1途径发挥抗病毒作用,还可作用于中性粒细胞、单核细胞、巨噬细胞、T细胞等,影响部分趋化因子的分泌和表达,在局部、全身抗炎症反应中起重要作用。
CXC chemokines, a class of small molecule proteins with similar structural functions and chemotactic attraction and activation, play an important role in mediating local and systemic inflammatory responses. Interferon (IFN) is a soluble glycoprotein with a broad spectrum of anti-viral, anti-tumor and immunomodulatory effects, mainly produced by monocytes and lymphocytes. IFN can not only play an antiviral effect through the PKR, 2’-5’OAS, Mx, ADAR1 pathways, but also act on neutrophils, monocytes, macrophages, T cells, etc., affecting the secretion of some chemokines And expression in the local, systemic anti-inflammatory response plays an important role.