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目的:观察鼻内气动喷射雾化吸入布地奈德混悬液对上呼吸道感染及鼻-鼻窦炎性疾病相关嗅觉障碍的临床治疗效果。方法:20例嗅觉障碍患者,相关病因包括鼻-鼻窦炎、变应性鼻炎、上呼吸道感染、嗅裂病。在进行治疗前,采用T&T嗅觉检查法和记录嗅觉事件相关电位(OERPs)对嗅觉功能进行评估。然后行鼻腔雾化吸入布地奈德混悬液(1mg,2ml),每天1次,共15次。每5次雾化吸入结束后,采用T&T嗅觉检查法复查嗅觉功能。15次雾化吸入全部结束后,同时复查T&T嗅觉识别阈和OERPs。结果:20例上呼吸道感染及鼻-鼻窦炎性疾病相关的嗅觉障碍患者经过鼻腔雾化吸入治疗,5例(25%)患者嗅觉功能恢复正常,10例(50%)患者嗅觉功能明显改善,3例(15%)患者嗅觉功能稍有改善,2例无效;总有效率为90%。结论:鼻腔气动喷射雾化吸入布地奈德混悬液对上呼吸道感染及鼻-鼻窦炎性疾病相关的嗅觉障碍患者具有较好治疗效果,该治疗方法简便、无创、有效,患者依从性好,是较好的治疗方法。
Objective: To observe the effect of intranasal aerosol injection of budesonide suspension on upper respiratory tract infection and allergic rhinosinusitis-related olfactory dysfunction. Methods: Twenty patients with olfactory dysfunction were involved in the etiology, including rhinosinusitis, allergic rhinitis, upper respiratory tract infection and olfactory dehiscence. Before treatment, olfactory function was assessed using T & T olfactory tests and recording of olfactory event-related potentials (OERPs). Then nasal inhalation budesonide suspension (1mg, 2ml), 1 times a day for a total of 15 times. Olfactory function was examined by T & T olfactory test after every 5 inhalations. After all 15 inhalation injections, T & T olfactory recognition thresholds and OERPs were also reviewed. Results: In 20 patients with upper respiratory tract infection and nasal sinusitis-related olfactory dysfunction, nasal inhalation therapy was performed. Olfactory function returned to normal in 5 patients (25%). Olfactory function was significantly improved in 10 patients (50%), Olfactory function was slightly improved in 3 patients (15%), 2 were ineffective, and the total effective rate was 90%. Conclusion: Aerosol inhalation of budesonide nasal aerosol spray on patients with upper respiratory tract infection and allergic rhinosinusitis has better therapeutic effect on patients with olfactory dysfunction. The treatment is simple, non-invasive, effective, patient compliance is good, Is a better treatment.