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目的探讨奥美拉唑治疗消化性溃疡出血的临床效果。方法选取60例消化性溃疡出血患者,随机分为两组,各30例。在常规止血治疗的基础上,观察组口服奥美拉唑,对照组口服法莫替丁。治疗1个月,观察两组患者的不良反应及临床效果。结果观察组止血时间(3.42±2.26)d,对照组为(8.16±1.25)d;观察组腹泻、心悸、头痛等不良反应发生率6.67%(2/30),对照组为13.33%(4/30)。两组差异均有统计学意义(P<0.05)。观察组治疗总有效率96.67%,对照组为83.33%,两组差异有统计学意义(P<0.05)。结论与法莫替丁相比,应用奥美拉唑治疗消化性溃疡出血,止血迅速,不良反应发生率低,临床症状改善显著,效果可靠。
Objective To investigate the clinical effects of omeprazole in the treatment of peptic ulcer bleeding. Methods Sixty patients with peptic ulcer bleeding were randomly divided into two groups (n = 30 in each group). On the basis of conventional hemostatic treatment, omeprazole was given orally in the observation group and famotidine in the control group. Treatment for 1 month, the two groups of patients were observed adverse reactions and clinical effects. Results The bleeding time in observation group was (3.42 ± 2.26) d, and that in control group was (8.16 ± 1.25) d. The incidence of adverse reactions such as diarrhea, palpitations and headache in observation group was 6.67% (2/30) and that in control group was 13.33% (4 / 30). The differences between the two groups were statistically significant (P <0.05). The observation group, the total effective rate was 96.67%, 83.33% in the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Compared with famotidine, the application of omeprazole in the treatment of peptic ulcer bleeding, rapid bleeding, the incidence of adverse reactions is low, significant improvement in clinical symptoms, the effect is reliable.