Notch is a very important geometry with widespread applications in engineering structural components. Finding a universal equation to predict the effect of notch on strength of materials is of much significance for structural design and materials selection. In the present work, we tried to find this universal equation from experimental results of metallic glasses(MGs) and other materials as well as theoretical derivations based on a universal fracture criterion(Qu and Zhang, Sci. Rep. 3(2013) 1117). Experimental results showed that the notch effect of the studied MG was affected by the notch geometry characterized by the stress concentration factor Kt.As Ktbecomes smaller, the notch strength ratio(NSR, which is the ratio of nominal ultimate tensile strength(UTS) of the notched sample to UTS of the unnotched sample) increases. By comparing MGs with other materials like brittle ceramics and ductile crystalline metals, we find that when Ktis same, the NSR is larger for ductile metals but smaller for brittle ceramics. Theoretically, we derived a universal equation for notch effect on strength of materials: NSR ? M/Kt, where M is a constant related to materials. This universal equation was found to be consistent with the experimental results. Notch is a very important geometry with widespread applications in engineering structural components. Finding a universal equation to predict the effect of notch on strength of materials is of much significance for structural design and materials selection. In the present work, we tried to find this universal equation from experimental results of metallic glasses (MGs) and other materials as well as theoretical derivations based on a universal fracture criterion (Qu and Zhang, Sci. Rep. 3 (2013) 1117). Experimental results showed that the notch effect of the studied MG was affected by the notch geometry characterized by the stress concentration factor Kt.As Ktbecomes smaller, the notch strength ratio (NSR, which is the ratio of nominal ultimate tensile strength (UTS) of the notched sample to UTS of the unnotched sample) increases By comparing MGs with other materials like brittle ceramics and ductile crystalline metals, we find that when Ktis same, the NSR is larger for ductile metals but smaller for brittle ceramics. Theoretically, we derived a universal equation for notch effect on strength of materials: NSR? M / Kt, where M is a constant related to materials. This universal equation was found to be consistent with the experimental results.