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1939年Crafoord等报道食道静脉曲张的硬化疗法,用一特制的注射针给18岁女性食道静脉曲张患者的曲张静脉中注入乌拉坦奎宁。二十世纪四十年代后半期由于各种门脉减压分流术的实施,以及当时缺乏目前的内镜及特制的穿刺针,因此硬化疗法仅用于不能行分流术患者的紧急止血。1978年高濑等报道在内镜下以5％乙醇胺油酸酯(EO)进行硬化疗法,由于其较手术疗法损害小,简单及效果好,其后于内镜下行硬化疗法迅速被广泛采用。本文报道其药理作用及临床应
In 1939 Crafoord et al reported esophageal varicosity sclerosis therapy, with a special injection needle for 18-year-old female patients with esophageal varicose vein varicose vein injection of ulatin quinine. In the latter half of the 1940s, sclerotherapy was only used for emergency hemostasis in patients who could not undergo shunts due to various portal decompression shunts and the lack of current endoscopy and specialized puncture needles. In 1978, Takase et al reported that endoscopic sclerotherapy with 5% ethanolamine oleate (EO) resulted in rapid and extensive follow-up of endoscopic sclerotherapy because of its less invasive, simpler and less invasive procedure than surgery. This article reports its pharmacological effects and clinical application