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本研究对６３例心、脑血管疾病患者进行了服药后３ｈ及（或）１周的临床观察，发现穿心莲（ＡＰＮ）对１及５ｍｉｎ血小板聚集率均有明显抑制作用（Ｐ＜０．００１），且随用药时间延长（１周后）疗效更显著。通过２０名志愿者服药前后血浆及血小板５－羟色胺（５－ＨＴ）测定证明ＡＰＮ能显著抑制血小板释放５－ＨＴ（Ｐ＜０．０１）。透射电镜观察到无论体外加药还是服药后ＡＰＮ均能明显抑制ＡＤＰ诱聚所致的血小板管导系统扩张及颗粒释放。其抗血小板聚集作用可能与激活血小板膜系统的腺苷环化酶，提高血小板内ｃＡＭＰ有关。
In this study, 63 patients with cardiac and cerebrovascular diseases were observed at 3h and/or 1 week after drug administration. It was found that Andrographis paniculata (APN) significantly inhibited platelet aggregation at 1 and 5 minutes (P<0.001). , And with the prolonged use of time (1 week later) the effect is more significant. The plasma and platelet serotonin (5-HT) levels before and after administration in 20 volunteers demonstrated that APN could significantly inhibit platelet 5-HT release (P<0.01). Transmission electron microscopy showed that APN inhibited platelet tube conduction system expansion and granule release caused by ADP priming in vitro and in vivo. Its anti-platelet aggregation may be related to activation of adenylyl cyclase in the platelet membrane system and increase of cAMP in platelets.