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目的：观察风湿性心脏病（ＲＨＤ）患者风湿活动期的血清一氧化氮（ＮＯ）、超氧化物歧化酶（ＳＯＤ）、过氧化脂质（ＬＰＯ）水平的变化及其临床意义。方法：用南京建成生物工程研究所生产的测试盒，按其提供的方法对４２例风湿活动期ＲＨＤ患者于抗风湿治疗前血清ＮＯ、ＳＯＤ和ＬＰＯ水平进行检测，分别与治疗后及４０例健康人对照组作对照。结果：风湿活动期ＲＨＤ患者于抗风湿治疗前血清ＮＯ、ＬＰＯ水平显著高于健康对照组，于治疗后显著下降；而ＳＯＤ活性显著低于健康对照组，于治疗后显著升高。结论：提示风湿活动期ＲＨＤ患者体内存在氧自由基代谢异常，ＮＯ在ＲＨＤ病理生理过程中起重要作用。
Objective: To observe the changes of serum nitric oxide (NO), superoxide dismutase (SOD) and peroxidation lipid (LPO) in patients with rheumatic heart disease (RHD) and their clinical significance. Methods: Twenty-four rheumatoid active RHD patients were tested for serum NO, SOD and LPO before and after anti-rheumatic therapy using the test box produced by Nanjing Jiancheng Institute of Bioengineering. The results were compared with that of 40 healthy subjects Human control group as a control. Results: The levels of serum NO and LPO in rheumatic active RHD patients before anti-rheumatic therapy were significantly higher than those in healthy controls and decreased significantly after treatment. The activity of SOD in rheumatoid active RHD patients was significantly lower than that in healthy controls and significantly increased after treatment. Conclusion: It is suggested that there is abnormal metabolism of oxygen free radicals in rheumatic active RHD patients. NO plays an important role in the pathophysiology of RHD.