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目的:检测类风湿关节炎(RA)患者外周血中凝血指标及其相关指标来评价临床意义。方法:选用RA50例为观察组,其中D-二聚体升高RA组40例,D-二聚体正常RA组10例;正常人40例为对照组。测定血浆凝血酶原时间(PT),活化部分凝血活酶时间(APPTT);血浆纤维蛋白原(FIB)和凝血酶时间(TT),血浆D-二聚体(D-Dimer)和纤维蛋白(原)降解产物(FDP),血浆抗凝血酶活性(AT:A);其他RA相关实验指标CRP,RF,抗CCP抗体,血沉。结果:RA组D-二聚体,FDP,FIB明显高于对照组(均P<0.01),RA组与对照组其他各指标无统计学意义;D-二聚体升高RA组RF,ESR,CRP明显高于D-二聚体正常RA组(均P<0.01),而抗CCP差别无统计学意义。结论:D-二聚体及凝血指标能及时反映RA患者体内凝血和纤溶系统失衡情况,对于RA病程发展和控制有其重要的临床指导价值。
Objective: To evaluate the clinical significance of coagulation indexes in peripheral blood of patients with rheumatoid arthritis (RA) and its related indexes. Methods: RA50 cases were selected as observation group, in which D-dimer increased in RA group 40 cases, D-dimer normal RA group 10 cases; 40 cases of normal control group. Plasma prothrombin time (PT), activated partial thromboplastin time (APPTT), plasma fibrinogen (FIB) and thrombin time (TT), plasma D-dimer and fibrin Original) degradation products (FDP), plasma antithrombin activity (AT: A); other RA related experimental indicators CRP, RF, anti-CCP antibody, ESR. Results: The D-dimer, FDP and FIB in RA group were significantly higher than those in control group (all P <0.01). There was no significant difference between RA group and control group. D-dimer increased the RF, ESR , CRP was significantly higher than D-dimer normal RA group (P <0.01), but the anti-CCP difference was not statistically significant. Conclusion: D-dimer and coagulation indexes can reflect the imbalance of coagulation and fibrinolytic system in patients with RA, and have important clinical value for the development and control of RA.