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目的：阐述经消化道急性有机磷农药中毒（ＡＯＰＰ）所致的呼吸衰竭的临床特点及救治经验．方法：对１１例急性胆碱能危象（ＡＣＣ）和７例中间综合征（ＩＭＳ）患者所引起的呼吸衰竭的症状、体征、血清胆碱酯酶（ＣｈＥ）活力等进行回顾性分析，并观察经洗胃、使用阿托品、胆碱酯酶重活化剂、呼吸机、血液沤流等的治疗效果。结果：所有患者均先后出现呼吸衰竭和急性胆碱能危象，血清ＣｈＥ活力为０；经抢救后治愈１１例（６１．ｌ％），死亡７例（３８．９％），主要死因为呼吸肌麻痹继发心跳停止。结论：ＡＣＣ和ＩＭＳ患者出现呼吸衰竭时应及时使用呼吸机治疗；早期机械通气支持有助于改善预后
Objective: To describe the clinical features and treatment experience of respiratory failure caused by acute organophosphorus pesticide poisoning (AOPP) in gastrointestinal tract. Methods: The symptoms and signs of respiratory failure and serum cholinesterase (ChE) activity in 11 patients with acute cholinergic crisis (ACC) and 7 patients with intermediate syndrome (IMS) were retrospectively analyzed. Observed after gastric lavage, the use of atropine, cholinesterase reactivation agent, ventilator, blood flow and other treatment effect. Results: Respiratory failure and acute cholinergic crisis occurred successively in all patients. Serum ChE activity was 0; 11 patients (61.1%) were cured and 7 died (38.9%) after resuscitation. The main cause of death was respiratory Myopia secondary to cardiac arrest. CONCLUSIONS: Respiratory failure should be promptly treated with ventilator in patients with ACC and IMS; early mechanical ventilation support may improve prognosis