论文部分内容阅读
提出一种基于电荷迁移反应简便可靠地测定头孢羟氨苄的分光光度法。在甲醇－乙醇介质中，头孢羟氨苄与氯冉酸于５０℃反应１５ｍｉｎ能够形成稳定的１：１络合物，其λｍａｘ＝５２８ｎｍ，线性范围为２０～４００ｍｇ／Ｌ。用拟定的方法测定原粉和胶囊，结果与药典法一致。对浓度１００ｍｇ／Ｌ的药物１０次测定相对标准偏差为１．４％，样品的标准加入回收率为９９．０％～１００．８％。
A spectrophotometric method for the simple and reliable determination of cefadroxil based on the charge transfer reaction was proposed. In methanol-ethanol medium, cefadroxil reacted with chlorrochloric acid at 50 ° C for 15 min to form a stable 1: 1 complex with a λmax = 528 nm and a linear range of 20-400 mg / L. The proposed method for the determination of the original powder and capsules, the results consistent with the pharmacopoeia. The relative standard deviation (RSD) of 10 times of the drug with the concentration of 100 mg / L was 1.4%, and the standard addition recovery of the sample was 99.0% ~ 100.8%.