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目的 探讨镉接触工人体内血清性激素水平的变化及其机制。方法 选取南方某冶炼厂镉接触工人及当地健康男性为调查对象 ,经空气采样测定各车间空气中镉的浓度 ,用原子吸收分光光度法测定尿镉 ,并经肌酐校正作为调查对象体内镉负荷的生物标记物 ;同时测定工人体内性激素水平 ,并进行镉接触的剂量 效应评定。结果 在控制年龄等混杂因素后 ,血清睾酮水平随镉接触水平的增高而呈升高趋势 ,其中尿镉为 1 0 9～ 2 1 9μmol/mol肌酐及 >2 1 9μmol/mol肌酐组的睾酮水平分别为 :1 3 0 0nmol/L和 1 1 37nmol/L ,与 0 0～ 2 2 μmol/mol肌酐组的 9 31nmol/L比较 ,差异有显著性 ;电解车间及尿镉 >2 1 9μmol/mol肌酐组工人的血清黄体生成素水平分别为 4 1 1U/L和 4 32U/L ,显著高于对照组的 2 52U/L和尿镉 0 0～ 2 2 μmol/mol肌酐组的 2 64U/L。 结论 镉接触能引起工人血清性激素水平的变化
Objective To investigate the changes of serum sex hormone levels in cadmium exposed workers and its mechanism. Methods Cadmium exposed workers and local healthy males from a smelter in South China were selected as samples to measure the concentration of cadmium in the air of each plant by air sampling. Urinary cadmium was determined by atomic absorption spectrophotometry and corrected for creatinine as cadmium load Biomarkers; Simultaneous determination of sex hormones in workers and evaluation of the dose response of cadmium exposure. Results Serum testosterone levels tended to increase with the increase of exposure to cadmium after control of age and other confounding factors. The levels of testosterone in urine with cadmium of 1 0 9 ~ 2 1 9μmol / mol and> 2 1 9μmol / mol creatinine Respectively, at 1300 nmol / L and 1137 nmol / L, which were significantly different from 931 nmol / L at 0 0 ~ 2 2 μmol / mol creatinine group; electrolysis shop and urine cadmium> 219 μmol / mol Serum luteinizing hormone levels of creatinine workers were 4 1 1U / L and 4 32U / L, respectively, which were significantly higher than those of 2 52U / L and 24U / L of urine cadmium 0 0 ~ 2 2 μmol / mol creatinine . Conclusion Cadmium exposure can cause changes in serum sex hormone levels in workers