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目的研究垂体后叶素联合米索前列醇用于预防产后出血的临床疗效。方法选取海西州人民医院妇产科2012年4—6月收治的40周阴道分娩产妇68例,按照随机数字表法分为对照组和观察组,每组34例。对照组给予催产素治疗,观察组给予垂体后叶素联合米索前列醇治疗,比较两组患者的血压、产后出血情况及不良反应情况。结果治疗前两组产妇舒张压和收缩压比较,差异无统计学意义(P>0.05);治疗后,观察组舒张压和收缩压均低于对照组,差异有统计学意义(P<0.05)。观察组产妇产后2、24h出血量均低于对照组,且观察组产后出血发生率(14.7%)低于对照组(38.2%),差异有统计学意义(P<0.05)。两组产妇在治疗过程中均未出现明显的不良反应。结论垂体后叶素联合米索前列醇用于预防产后出血疗效显著,不良反应少,值得临床使用和推广。
Objective To study the clinical effect of vasopressin combined with misoprostol in preventing postpartum hemorrhage. Methods Sixty-eight cases of vaginal delivery in April-June, 2012 in Haixi People’s Hospital of Obstetrics and Gynecology were divided into control group and observation group according to random number table method, with 34 cases in each group. The control group was treated with oxytocin. The observation group was treated with pituitrin combined with misoprostol. The blood pressure, postpartum hemorrhage and adverse reactions in the two groups were compared. Results Before treatment, there was no significant difference in diastolic blood pressure and systolic blood pressure among the two groups (P> 0.05). After treatment, the diastolic and systolic pressures in the observation group were lower than those in the control group (P <0.05) . The amount of bleeding in the observation group was lower than that in the control group at 2 and 24 hours after birth, and the incidence of postpartum hemorrhage in the observation group was 14.7% lower than that in the control group (38.2%). The difference was statistically significant (P <0.05). Two groups of mothers in the course of treatment did not appear obvious adverse reactions. Conclusion Psoralen combined with misoprostol for the prevention of postpartum hemorrhage significant effect, less adverse reactions, it is worth clinical use and promotion.