本文通过临床研究及动物实验。对食道调搏测定窦房结有效不应期(SNERP)的方法学进行了详细研究。提出测定SNERP的适应症,SNERP的3条判断标准,测SNERP的最佳起搏周期为≥800毫秒,刺激迷走神经不引起SNERP延长,SNERP可有效地鉴别单纯窦缓与病窦患者,早期病窦SNERP的检出率显者高于晚期病窦,故有利于病窦的早期诊断。将SNFRP≥600毫秒作为异常,对病窦诊断的敏感度、特异度和诊断效率分别为60％、94％和86％。 This article through clinical research and animal experiments. The method of esophageal pacing determination of effective refractory period of sinoatrial node (SNERP) was studied in detail. Put forward the determination of indications of SNERP, SNERP three criteria, the best pacing cycle measured SNERP ≥ 800 ms, to stimulate the vagus nerve does not cause prolonged SNERP, SNERP can effectively distinguish simple sinus and sick sinus patients, early sick sinus SNERP was significantly higher than the detection rate of advanced sinus disease, it is conducive to the early diagnosis of sick sinus. Using SNFRP ≥ 600 ms as an anomaly, the sensitivity, specificity, and diagnostic efficiency of diagnosing sick sinus were 60%, 94%, and 86%, respectively.