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目的用化学发光法检测心力衰竭患者血浆BNP水平,研究心力衰竭时血浆BNP的变化及其临床评价。方法采用化学发光法测定76例(38例住院心力衰竭患者及38例对照者)血浆BNP浓度。结果在心力衰竭患者中血浆BNP浓度显著高于正常对照组(P=0.0003),且患者血浆BNP水平与其心力衰竭严重程度呈正相关(r=0.698)。结论心力衰竭患者血浆BNP浓度显著升高,且与心力衰竭的严重程度呈正比,具有一定的临床意义。
Objective To detect plasma BNP levels in patients with heart failure by chemiluminescence and to investigate the changes of BNP in patients with heart failure and its clinical evaluation. Methods Plasma BNP levels were measured in 76 patients (38 hospitalized patients with heart failure and 38 controls) by chemiluminescence method. Results The plasma BNP level in patients with heart failure was significantly higher than that in the normal control group (P = 0.0003). The plasma BNP level was positively correlated with the severity of heart failure (r = 0.698). Conclusions Plasma BNP levels in patients with congestive heart failure are significantly increased, which are in direct proportion to the severity of heart failure and have certain clinical significance.