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产前母体处于应激状态下,可以削弱子代的神经系统对外界不良刺激影响的抵抗能力.但产前应激状态是否可以影响抗精神疾病药物对动物行为的增益作用,目前还没有明确的结论.此外,在动物实验中,动物需要经常接受注射操作,注射操作本身是否会影响动物行为,尚未有相关研究.在本实验中,探索了产前轻微应激状态、围产期注射操作和抗精神疾病药物对动物行为可能的交互影响.母鼠在经历产前轻微应激状态后生产子代,雄性仔鼠在围产期(日龄第7,9,11天)不接受注射或接受盐水或奥氮平注射(2 mg/kg,腹腔注射).在其亚成年期(日龄第35天)和成年期(日龄第60天),观察其社交和嗅觉辨识行为,分析了总探索时间和对新旧刺激的偏好程度两个参数.我们发现,围产期重复注射操作可以改变产前应激组大鼠在社交和嗅觉辨识实验中的偏好程度,对无应激组大鼠没有影响.奥氮平注射可以增长无应激组大鼠在社交活动中的总探索时间,对应激组大鼠没有影响.研究表明,产前轻微应激状态可以易化诸如围产期注射操作等不良环境刺激导致的行为异常,并减弱抗精神疾病药物的对神经系统的影响.
Prenatal maternal under stress can weaken the offspring’s nervous system’s resistance to adverse external stimuli.But whether prenatal stress can affect the antipsychotic effect of drugs on animal behavior, there is no clear In addition, in animal experiments, animals often need to accept the injection operation, injection operation itself will affect animal behavior, there is no relevant research.In this experiment, to explore the prenatal mild stress, perinatal injection and Interactions of antipsychotics agents with animal behavior may occur: Dams were born after experiencing mild prenatal stress and male offspring were not injected or accepted during the perinatal period (days 7, 9 and 11) Saline or olanzapine injection (2 mg / kg, intraperitoneal injection) .The social and olfactory identification behaviors were observed in their sub-adulthood (35th day) and adulthood (60th day), and the total Explore the time and the degree of preference for old and new stimuli.We found that perinatal repeated injections can change the preference of prenatal stress group in social and olfactory identification experiments in rats without stress Effect Injecting can increase the total exploration time of non-stress rats in social activities, had no effect on stress rats.Studies show that pre-natal mild stress can be facilitated by adverse environmental stimuli such as perinatal injection Behavioral abnormalities and diminish the nervous system effects of antipsychotic medications.