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Latamoxef(LMOX)适用于妇产科感染性疾病如子宫内感染、子宫副件炎、子宫旁结缔组织炎、骨盆盆腔炎等。为了获得高的临床疗效,期望药物应用后在这些组织内能达到高浓度。作者选择年龄30～54岁的肝、肾功能正常妇女23例,分成5组,分别于静脉滴注LMOX2g(持续1小时)后30、60、90、120和180分钟测定血清和各组织浓度。血清浓度测定结果表明,点滴开始后30分的平均值为125.0μg/ml,点滴结束,即开始后1小时为最高(平均134.1μg/ml),以后渐降,120分后平均血浓度为61.3μg/ml,180
Latamoxef (LMOX) for obstetrics and gynecology infectious diseases such as intrauterine infection, vice accessory inflammation, para-uterine connectiveitis, pelvic inflammatory disease and so on. In order to achieve high clinical efficacy, it is expected that high concentrations will be achieved in these tissues after drug administration. The authors selected 23 healthy women and aged 23 to 54 years old with normal liver and kidney function and divided them into 5 groups. Serum and tissue concentrations were measured at 30, 60, 90, 120 and 180 minutes after intravenous injection of LMOX2g (for 1 hour). The results of serum concentration showed that the average value of 30 minutes after the start of drip was 125.0μg / ml, and the drip rate was the highest (average 134.1μg / ml) 1 hour after the start of drip. After 120 minutes, the average blood concentration was 61.3 μg / ml, 180