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目的:研究干姜、辛夷、荜橙茄3种挥发油和氮酮及其两两等量组合后对罗通定的经皮促渗作用。方法:采用改良的Franz扩散池进行小鼠体外经皮渗透实验。以UV法及HPLC法测定罗通定的累积渗透量,筛选对罗通定有最佳促渗作用的挥发油。结果:3种挥发油对罗通定均具有促渗作用,其中5%荜橙茄油、5%干姜油、2.5%荜澄茄油+2.5%氮酮对罗通定的8 h平均累计渗透量(Q8,mg/cm2)分别为:6.0758、6.1148、6.5487;4 h的增渗倍数分别为:1.01、1.00、1.13。结论:2.5%荜澄茄油+2.5%氮酮对罗通定的促渗效果最好。
OBJECTIVE: To study the transdermal effect of three kinds of volatile oil and azone and the equivalent combination of dry ginger, Magnolia biondii and Radix Angelica sinensis on peritoneal permeability of Luo Tongding. Methods: A modified Franz diffusion cell was used to in vitro transdermal penetration test in mice. The cumulative permeation amount of Luo Tongding was determined by UV and HPLC, and the volatile oil with the best promoting effect on Luo Tongding was screened out. Results: The three kinds of volatile oil had a promoting effect on Luo Tongding. The average cumulative infiltration rate of Luo Tongding for 5 h, orange oil, 5% ginger oil, 2.5% azeotrope oil and 2.5% azone Quantities (Q8, mg / cm2) were: 6.0758,6.1148,6.5487; 4 h multiplication rates were: 1.01,1.00,1.13. CONCLUSION: 2.5% 荜Shedo oil + 2.5% Azone could promote LuoTongDing best.