最早人们认为动脉粥样硬化是一种由于随年龄增长的退行性改变。自 1970年后大量证据表明 ,动脉粥样硬化与血管在损伤后发生的一系列生物学过程有关。近来 ,Ross及其他学者发现血管受损伤后产生炎症 -纤维增殖反应 ,其中涉及大量的生长因子、细胞因子及血管调节分子 ,最终导致动 Atherosclerosis was first thought to be due to a degenerative change with age. There has been a great deal of evidence since 1970 that atherosclerosis has been linked to a series of biological processes that occur after blood vessels have been damaged. Recently, Ross and other researchers have found that inflammation-fibrotic responses occur after vascular injury, involving a large number of growth factors, cytokines, and vascular regulatory molecules that eventually lead to