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为研究比索洛尔的降压疗效及其对肾素 血管紧张素 醛固酮系统及血管内皮功能的影响 ,选择 72例初诊原发性高血压病人口服比索洛尔 4周 ,观察治疗前后诊室血压及血浆肾素、血管紧张素Ⅱ、醛固酮、内皮素质量浓度和一氧化氮浓度的变化。发现 :比索洛尔治疗 4周后 ,诊室收缩压和舒张压的下降幅度分别为 2 .16kPa( 16 .2 3mmHg)和 1.0 2kPa( 7.6 5mmHg) ,与服药前相比差异有非常显著性 (P <0 .0 1) ;肾素、血管紧张素Ⅱ、醛固酮降低 ,一氧化氮升高 (P <0 .0 5) ;而内皮素、一氧化氮 /内皮素比值无明显变化。提示 :比索洛尔能够有效抑制肾素、血管紧张素、醛固酮系统及改善血管内皮功能 ,达到降低血压和保护靶器官的目的
In order to study the antihypertensive effect of bisoprolol and its effect on renin-angiotensin aldosterone system and endothelial function, 72 patients with newly diagnosed essential hypertension were selected for oral administration of bisoprolol for 4 weeks, and the clinic blood pressure and blood plasma Renin, angiotensin Ⅱ, aldosterone, endothelin concentration and nitric oxide concentration changes. After 4 weeks of bisoprolol treatment, systolic and diastolic blood pressures decreased by 2.16 kPa (16.23 mmHg) and 1.02 kPa (7.65 mmHg), respectively, with significant differences (P <0.01). Renin, angiotensin II, aldosterone and nitric oxide were increased (P <0.05), while the ratios of ET and NO / ET did not change significantly. Tip: Bisoprolol can effectively inhibit renin, angiotensin, aldosterone system and improve vascular endothelial function, to lower blood pressure and protect the target organ