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在生产环境空气中,石英尘的浓度和分散度,直接决定粉尘对人体的危害程度。在一定程度上,粉尘的浓度和分散度越高,矽肺发病越快,病变也越严重。但是关于它的浓度和分散度与其细胞毒性的关系,至今报道较少。 根据巨噬细胞吞噬石英尘后的崩解是矽肺发病的重要环节的理论,本研究应用体外细胞培养技术,比较不同浓度和分散度的石英尘,视其细胞毒作用的强弱,以期为阐明矽肺病变程度与石英尘剂量和分散度之间的关系提供实验依据。
In the production environment, the concentration and dispersion of quartz dust directly determines the degree of dust damage to the human body. To some extent, the higher the concentration and dispersion of dust, the faster the incidence of silicosis, the more serious the disease. However, little has been reported about the relationship between its concentration and dispersibility and its cytotoxicity. According to the disintegration of macrophages after phagocytosis of quartz dust is an important part of the pathogenesis of silicosis, in this study, in vitro cell culture techniques were used to compare the different concentrations and dispersion of quartz dust, depending on the strength of its cytotoxicity, with a view to clarify The relationship between the degree of silicosis and the amount and dispersion of quartz dust provides experimental evidence.