目的通过检测部分肿瘤患者HLA-DQ座位的7个等位基因位点,探讨HLA-DQ基因多态性与人体部分肿瘤的关联性。方法采用PCR-SSP(聚合酶链反应-序列特异性引物)技术,检测36例部分肿瘤患者的HLA-DQ基因位点7个,并以144例健康人作为对照。结果实验组HLA-DQ9基因频率(29.2%)明显高于对照组(7.64%),RR(相对危险度)=5.04,P<0.05(P=0.001),差异有统计学意义。实验组其他HLA-DQ座位基因频率与对照组比较差异无统计学意义。结论 HLA-DQ9可能为人体部分肿瘤的易感基因。 Objective To detect the association of HLA-DQ gene polymorphism with partial tumor in human by detecting seven alleles of HLA-DQ locus in some cancer patients. Methods PCR-SSP (polymerase chain reaction-sequence specific primer) technique was used to detect HLA-DQ gene loci in 36 patients with partial tumor, and 144 healthy controls were used as controls. Results The frequency of HLA-DQ9 gene in experimental group was significantly higher than that in control group (29.2% vs RR = 5.04, P <0.05). The difference was statistically significant. There was no significant difference in the frequency of other HLA-DQ locus genes in the experimental group compared with the control group. Conclusion HLA-DQ9 may be a susceptible gene in human tumor.