新生儿缺氧缺血性脑病(hypoxie ischaemic eneephalopatby,HIE)是新生儿期比较常见的合并症,由围生期窒息引起的部分或完全缺氧、脑血流减少或暂停所致,重度患儿常有脑瘫、智力障碍等后遗症,给家庭及社会带来沉重的负担~([1])。近年来,随着新生儿科治疗技术的不断进步,HIE的生存率和预后得到了显著改善,但该病的致残率并没有显著下 Hypoxic ischemic encephalopathy (HIE) is a common comorbidity in the neonatal period caused by partial or complete hypoxia caused by perinatal asphyxia, decreased or stopped cerebral blood flow, severe children Often cerebral palsy, mental retardation and other sequelae, to the family and society a heavy burden ~ ([1]). In recent years, with the progress of neonatal therapies, the survival rate and prognosis of HIE have been significantly improved, but the morbidity of the disease is not significant