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原白头翁脑(Protoanemonin)广泛存在于毛茛科植物毛茛、茴茴蒜之中;原白头翁脑曾用于治疗关节炎、哮喘、肝炎等,且有广谱抗菌作用。我院肿瘤科用于治疗癌症有一定效果但,原白头翁脑刺激性大、不稳定,且易聚合而失败;而原白头翁脑的前体物毛茛甙经临床试用,对肺癌等有效,其抗癌活性亦为药理实验证实。毛茛甙虽克服了原白头翁脑刺激性大和不稳定的缺点,但用量较大;为此,笔者制备了原白头翁脑的亚硫酸氢钠加成物(以下简称加
The original Pulsatilla brain (Protoanemonin) is widely found in the Ranunculus plant Ranunculus squamosa, and the peony anise garlic. The Pulsatilla pilosa has been used to treat arthritis, asthma, hepatitis, etc., and has a broad-spectrum antibacterial effect. The oncology department of our hospital has certain effects for the treatment of cancer. However, the original Pulsatilla brain is irritating and unstable, and it is easy to polymerize and fail. The original Pulsatillae brain precursor, trichomes, has been clinically tested and is effective against lung cancer and its resistance. Cancer activity is also confirmed by pharmacological experiments. Although Mao Duo overcomes the shortcomings of the original Pulsatilla brain irritation and instability, but the amount is larger; for this reason, I prepared the original Pulsatilla brain sodium bisulphite adduct (hereinafter referred to as plus